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However, in most cases, cancer cells seem to be resistant to cellular reprogramming.

Furthermore, the underlying mechanisms of limited reprogramming in cancer cells are largely unknown.

The advancement in the field of reprogramming technology has provided tools for generating patient- specific induced pluripotent stem cells (hi PSCs) as well as human induced neuronal progenitor cells (hi NPCs). Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.Furthermore, we performed serial BM transplantation to demonstrate that the DNA damage-induced expanded FA HSC compartment contained pre-leukemic stem cells that required the NHEJ activity of DNA-PKcs to induce leukemia in the secondary recipients.Read More: Several recent studies have claimed that cancer cells can be reprogrammed into induced pluripotent stem cells (i PSCs).By continuing to use this site, you consent to the use of cookies.We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services.

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